bioaccumulation of lead in the tissues of japanese quails and its effects on blood biochemical factors

background: lead is the oldest known toxic metal, physiologically and biologically harmful to living creatures. this study aimed to evaluate the lead accumulation in the liver and breast muscles of japanese quail (coturnix japonica) and to compare concentrations in both sexes and its effect on blood biochemical factors. methods: twenty-four young farm japanese quails (25 day old) prepared from local breeders in december 2014 and randomly divided into control and treatment group. treatment group were exposed to 0.4 mg per kg diet of “lead acetate” for 21 days. we studied the effects of lead on survival and blood biochemical factors. the lead accumulation in the liver and breast muscles of japanese quail was determined using atomic absorption. results: exposure to lead caused a significant increase in the activity of enzymes (ast), (alt), (ldh), glucose, creatinine and uric acid in poultry treated with lead compared with the control group (p<0.05). in addition, significant decrease in the activity of alp, ache, total protein, albumin, globulin, and triglycerides was found (p<0.05). the treated group had no significant change in the activity of cpk and cholesterol. lead accumulation was more in the liver rather than the breast muscle. there was no significant difference between males and females as for concentration of lead in muscle and liver of quail. conclusion: quail have capabilities to accumulate lead in their tissues. in addition, it can lead to apparent changes in enzymes and blood biochemical factors, which show adverse effects of heavy metals on the immune and physiological system of birds.